Saulnier DM, et al. The intestinal microbiome, probiotics and prebiotics in neurogastroenterology. Gut Microbes. 2013;4(1):17–27. This can be very helpful, as the microbes in our gut are strongly influenced by our environment, including universally common factors such as diet, medication use, stress levels and exercise. Depletion of beneficial bacteria, because of an unhealthy diet low in fruit and vegetables, or antibiotic intake, can upset the delicate balance of our gut microbiome and allow the growth of less desirable micro-organisms. This is known as dysbiosis. Learn more by reading What is dysbiosis?Using a synbiotic ensures that the probiotics in the supplement will have a food source in the gut, though it is still important to eat a healthy balanced diet full of fruit and vegetables. Horvath A, Leber B, Feldbacher N, Tripolt N, Rainer F, Blesl A, Trieb M, Marsche G, Sourij H, Stadlbauer V (2020) Effects of a multispecies synbiotic on glucose metabolism, lipid marker, gut microbiome composition, gut permeability, and quality of life in diabesity: a randomized, double-blind, placebo-controlled pilot study. Eur J Nutr 59:2969–2983 Borenstein M, et al. A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods. 2010;1(2):97–111. Rabiei S, HedayatiM,Rashidkhani B, Saadat N, Shakerhossini R (2019) The effects of synbiotic supplementation on body mass index, metabolic and inflammatory biomarkers, and appetite in patients with metabolic syndrome: a triple-blind randomized controlled trial. J Diet Suppl 16:294–306

The third subgroup analysis was based on different types of interventional agents, including prebiotics or agents containing probiotics (i.e., probiotics and synbiotics) (Fig. 3c). The pooled effects of agents containing probiotics on depression were significant ( SMD = -0.35[-0.47, -0.22], P< 0.001), accompanied by slightly increased heterogeneity ( I 2 = 38.2%, P = 0.047). However, in three studies with prebiotic intervention, the reduction in depressive symptom scores showed no significant difference from the placebo group ( SMD = -0.25[-0.64,0.15], P = 0.221). The heterogeneity of the prebiotic subgroup was nonsignificant ( I 2 = 28.7%, P = 0.103). In addition, the heterogeneity between those two groups was not significant ( P = 0.624). Yes. We believe that probiotics and prebiotics, alongside diet, nutrition, exercise, and lifestyle, are cornerstone tools to building foundational health. Clinical research shows that continuous, daily intake is the best way to get the most out of your synbiotic. By signing up for a subscription, you’ll easily be able to build DS-01® into your routine. The most important thing is still to choose the strains of probiotics most suited to your individual needs. Probiotics are beneficial bacteria that can help to re-establish the normal microbiota. They are particularly effective when delivered together with a prebiotic, a source of nutrition that stimulates growth.

Arena MP, Russo P, Capozzi V, Rascón A, Felis GE, Spano G, Fiocco D (2016) Combinations of cereal β-glucans and probiotics can enhance the anti-inflammatory activity on host cells by a synergistic effect. J Funct Foods 23:12–23 Zhang X, et al. Effects of fermented milk containing Lacticaseibacillus paracasei strain Shirota on constipation in patients with depression: a randomized, double-blind, placebo-controlled trial. Nutrients. 2021;13(7):2238. Biagi E, et al. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One. 2010;5(5):e10667. Björklund M, Ouwehand AC, etal. (2012). "Gut microbiota of healthy elderly NSAID users is selectively modified with the administration of Lactobacillus acidophilus NCFM and lactitol". Age (Dordr). 34 (4): 987–99. doi: 10.1007/s11357-011-9294-5. PMC 3682059. PMID 21853265. Its probiotic blend contains a synergistic formula of 13 powerful probiotic strains designed for digestive and immune health. It includes Bifidobacterium lactis HN019 , Lactobacillus rhamnosus L08R , Lactobacillus acidophilus, Lactobacillus gasseri L22G, and more.

Johnson-Henry, K. C; Abrahamsson, T. R; Wu, R. Y; Sherman, P. M (2016). "Probiotics, Prebiotics, and Synbiotics for the Prevention of Necrotizing Enterocolitis". Advances in Nutrition. 7 (5): 928–37. doi: 10.3945/an.116.012237. PMC 5015037. PMID 27633108.This article needs more reliable medical references for verification or relies too heavily on primary sources. Please review the contents of the article and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed. Amongst studies applying probiotics as the intervention, 4 studies used a single strain, and the remaining 7 studies used multiple strains. The depressive symptom scores were reduced significantly, regardless of whether single or multiple strains were applied (multiple: SMD = -0.27 [-0.43, -0.10], P = 0.002; single: SMD = -0.42[-0.62, -0.22], P< 0.001). Additionally, no significant heterogeneity between groups was observed ( P = 0.249), with significant heterogeneity within the subgroup of multiple strains ( I 2 = 53.6%, P = 0.014), and absent heterogeneity within the subset of single strain ( I 2 = 0.0%, P = 0.817) (Fig. 3d). Hieronymus F, et al. Influence of baseline severity on the effects of SSRIs in depression: an item-based, patient-level post-hoc analysis. Lancet Psychiatry. 2019;6(9):745–52.